in lung pathology of Goodpasteur syndrome, the epitopes of alpha 3 chain of type 4 collagen which is a quarternary structure are normally sequestered in the collagen IV hexamer and can be exposed by infection, smoking, oxidants, or solvents, so that MHC T cells can attack it. Similarly what makes/triggers MHC T cells to attack the GBM? Is it the same risk factors as seen in lung pathology or different from that?
Sorry, I don’t understand your question. Plz elaborate
the risk factors for Goodpasteur syndrome affecting kidney is same as affecting lungs or different from others? That is my question mam.