In mechanism of action of pertusis toxin it is said that it causes adp ribosylation of alpha subunit of Gi protein and causes increase in camp …maam is it a printing error …should it be Gs protein?..
Pertussis acts via Gi protein only; should be - decreases cAMP.
Not decrease but increase cAMP
ok mam ya got confused; now clear
Pertussis toxin- MOA
ADP ribosylation of alpha subunit of Gi protein leads to increase activity of adenyl cyclase
maam but if it is acting through Gi it must have decreased camp …?
Mama for example the etec toxin which is acting through Gs protein is increasing camp
Please explain maam ?
Bachche please check the delta video
I have shown an image explaining this