In parietal cells of stomach which receptor is present M3 or M1

in parietal cells of stomach which receptor is present M3 or M1 in your video you have mentioned M1 is responsible for increased HCL secretion but in Goodman and gillman it is mentioned M3 is responsible for secretion.

Muscarinic Receptors in Parietal Cells

  • M3 Receptors: These are the predominant receptors on the parietal cells that, when activated by acetylcholine, lead to increased HCl secretion. The binding of acetylcholine to M3 receptors activates a G-protein, which in turn increases intracellular calcium levels and stimulates the proton pumps responsible for acid secretion.
  • M1 Receptors: Although M1 receptors are also present in the gastric mucosa, they are primarily found on the enterochromaffin-like (ECL) cells. Activation of M1 receptors on ECL cells stimulates the release of histamine, which then acts on H2 receptors on parietal cells to promote acid secretion indirectly.

Key Points

  • Direct Pathway: M3 receptors on parietal cells directly stimulate acid secretion.
  • Indirect Pathway: M1 receptors on ECL cells stimulate histamine release, which then stimulates H2 receptors on parietal cells, leading to increased acid secretion.


  • Goodman and Gilman’s Pharmacological Basis of Therapeutics: This authoritative source correctly indicates that M3 receptors are responsible for direct stimulation of HCl secretion in parietal cells.
  • Other Textbooks and Research: Many pharmacology and physiology textbooks, as well as primary research articles, support the role of M3 receptors in direct stimulation of parietal cells for acid secretion.


Your reference to Goodman and Gilman’s is accurate, and the correct information is that M3 receptors are the primary receptors on parietal cells responsible for the direct increase in HCl secretion.