In the management of a cardiac arrhythmia, lidocaine is to be administered by way of an IV loading dose

In the management of a cardiac arrhythmia, lidocaine is to be administered by way of an IV loading dose

A. renal clearance
B. bioavailability
C. volume of distribution
D. lag time
E. time to steady-state

Answer: C. Back to basic principles! Recall that to calculate a loading dose
you must know volume of distribution and target plasma concentration.
Since lidocaine is being given IV, its bioavailability is 100% (f=1) so no
adjustment is required to the equation. Renal clearance is needed to calculate
a maintenance dose, and time to steady-state applies only when using a main

tenance dose. There is no lag time for an IV drug.