isn’t Carvedilol preferred to reduce the portal blood flow ?
•Non selective Beta blockers like propanolol and nadolol + octreotide and Vasopressin mainly act by DECREASING portal blood flow
•Carvedilol has 2 actions: it decreases portal venous flow by Non selective Beta blockade+ it also has mild anti-alfa1 blockade action due to which it also DECREASES hepatic Vascular Tone and RESISTANCE
Carvedilol is a potent noncardioselective beta-blocker, with weak vasodilating properties because of alpha 1 blockade. A reduction in both intrahepatic and portocollateral resistance contribute to enhanced effects on portal pressure.