It increases or dec risk?

In Alzheimer, what is role of Apo E-4, it increases or dec risk?

Alzheimer’s risk Factors:

Most important risk factor: Old age

Other risk factors – Family history, presenilin-1, presenilin-2, Apolipoprotein E4 (ApoE ε4 allele), Ubiquitin, Down syndrome and smoking.

Protective factors: NSAIDs and Apolipoprotein E2. Thank you.

Apo E4increases the risk and Apo E2 decreases the risk

Increases Chris Hemsworth is biallelic for this,took a break from acting

apo E2 decreses risk of alzheimer as it is protective for it