Lesch–Nyhan syndrome is caused by deficiency of which enzyme

Lesch–Nyhan syndrome is caused by
deficiency of which enzyme?
a) Orotate Phosphoribosyltransferase
b) Uracil phosphoribosyltransferase
c) Quinolinate Phosphoribosyltransferase
d) Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Correct Answer - D
Answer: D. Hypoxanthine-guanine phosphoribosyltransferase
(HGPRT)
The condition is called ksch-Nyhan slmdrome, in which there is
complete deficiency of HGPRT.
HGPRT deficiency causes decreased utilization
of PRPP in salvage pathway.
This results in increased production of purine nucleotide from PRPP
via de-novo pathway.
The disease is characterized by hyperuricemia,
gouty arthritis, urinary stones, neurological symptoms.