Main receptors for semaphorins are plexins

● A membrane proteins that act as axonal growth cone guidance molecules.
● important in neural system development.
● main receptors for semaphorins are plexins.
● FUNCTIONS:- apoptosis, tumorigenesis, angiogenesis, neurodegenerative disease and axonal regeneration.

1)semaphorin 3a:-
a) marker for disease activity and potential immunoregulator in SYSTEMIC LUPUS ERYTHEMATOSUS.
b) Alzheimer’s disease (AD)
2) schizophrenia
3) parkinsonism