Mechanisms of Cancer Stem Cell Therapy Resistance

Mechanisms of Cancer Stem Cell Therapy Resistance

Conventional therapies are often not sufficient to eliminate CSC populations because of intrinsic resistance mechanisms and epigenetic plasticity of the cells (123, 124). This means in many cases, tumor relapse is caused by the incomplete elimination of all CSCs, since a single CSC seems to be sufficient to regrow a tumor

The role of cancer stem cells in drug resistance. Standard chemotherapeutics are not able to kill cancer stem cells (CSCs), which can promote tumor regrowth and eventually result in disease relapse. Different mechanisms, including increased.