Most severe NTD is rachiasis or anencephaly?

Most severe NTD is rachiasis or anencephaly?

Both rachischisis and anencephaly are severe neural tube defects (NTDs), but they present differently and have distinct implications.

  1. Anencephaly: Anencephaly is a condition where the neural tube fails to close at the base of the skull during fetal development. This results in the absence of a major portion of the brain, skull, and scalp. Babies with anencephaly are usually born without the front part of the brain (forebrain) and the top of the skull. This condition is fatal, and affected babies are typically stillborn or die shortly after birth. Anencephaly is considered one of the most severe NTDs due to the profound lack of brain development and the absence of vital structures necessary for life.
  2. Rachischisis: Rachischisis is a type of NTD characterized by the incomplete closure of the neural tube along the length of the spine, resulting in an open defect in the spinal cord and vertebrae. This condition leaves the spinal cord exposed and unprotected. Rachischisis can lead to severe neurological deficits, including paralysis and loss of sensation below the level of the defect. While rachischisis is also a serious condition, it may not always be immediately fatal, and outcomes can vary depending on the extent and location of the defect.

In summary, both anencephaly and rachischisis are severe NTDs with significant implications for affected individuals. Anencephaly is typically considered more severe due to the absence of essential brain structures, leading to a lack of viability. Rachischisis, while also serious, may result in varying degrees of neurological impairment depending on the extent of the spinal cord defect.