MUCORALES- Aseptate hyphae or Coenocytic hyphae- broad ribbon like hyphal forms
MCC of mucormycosis - Rhizopus (47%)
Others- Mucor
Cunninghamella
Apophysomyces
Lichtheimia
Saksenaea
Rhizomucor
Risk factors for mucormycosis-
Diabetes
Hematologic malignancy
HSCT
SOTR
Deferoxamine therapy
Note - HIV is not a risk factor
MC type-Rhino-oculo-cerebral disease
Drugs useful against Mucorales : AmB (DOC), Posaconazole, Isavuconazole
Drugs ineffective against Mucorales-
All echinocandins, Flucytosine, Fluconazole, Voriconazole
Variable effectiveness( depends on genus/ species)- Terbinafine and Itraconazole.