Multiple sclerosis is a demyelinating disease

Multiple sclerosis is a demyelinating disease in which both phospholipid and
sphingolipid levels are decreased, while lipid storage diseases exhibit accumulation of lipid substances (sphingolipid, ceramide) in brain (incorrect answers b, c, and e).
Multiple sclerosis exhibits multifactorial determination with autoimmune characteristics with susceptibility influenced by DNA and HLA markers. Ceramide is an important signaling molecule for apoptosis and is a precursor for glycosphingolipids and gangliosides; it does not form a major component of myelin (incorrect answer
a). Sphingolipids and phospholipids are structural lipids in membranes and myelin that insulate the nervous system; patchy loss of this insulation in multiple sclerosis
causes variable, episodic symptoms in vision, hearing, bladder control, sensation, and behavior.