My doubt is if osteoclasts are not developed properly how will it dissolve hydroxypatite? So its levels should also decrease in knocked out mice?
Ya so if hydroxyapatite resorption is defective, it’s level should increase na
The question specifies ‘hydroxyapatite levels in the bone’. Thus, in these knock-out animals, due to defective osteoclasts, bone resorption is decreased due to the low secretion of acid proteases. Hydroxyapatite from the bone is not being dissolved as a consequence, leading to increased hydroxyapatite levels in the bone. Thank you.