Needle aspiration reveals malignant ductal epithelial cells

A 53-year-old woman discovers a lump in her breast and physical examination confi rms a mass in the lower, outer quadrant of the left breast. Mammography demonstrates an ill-defi ned, stellate density measuring 1 cm. Needle aspiration reveals malignant ductal epithelial cells. A modifi ed radical mastectomy is performed. The surgical specimen reveals a fi rm irregular mass (arrows). Which of the following cellular markers would be the most useful to evaluate before considering therapeutic options for this patient?

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  1. Collagenase
  2. Estrogen receptors
  3. Galactosyltransferase
  4. Lysosomal acid hydrolases
  5. Myeloperoxidase