A 45-year-old man has abnormal circadian variation in body temperature, disruption of the sleep-wake cycle, and an impaired nocturnal surge of secretion of melatonin. An MRI of the brain is most likely to show a lesion involving which of the following nuclei?
The nucleus involved with circadian rhythms, sleep-wake cycle and melatonin regulation is the suprachiasmatic nucleus of the hypothalamus (option D).
Accessory optic nucleus (A) is involved involved in eye movements.
The lateral preoptic nucleus (B) is part of heat regulation in the hypothalamus. The pretectal © is the area in the midbrain related to pupillary light reflex.
The supraoptic nucleus (E) of the hypothalamus regulates water balance and the produces ADH and oxytocin