Neuronal migration disorder (nmd) :-

NEURONAL MIGRATION DISORDER (NMD) :-

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■ Heterogenous group of disorders caused by the abnormal migration of neurons in the developing brain and nervous system.

■ DCX( double-cortin gene), LIS1, and filamin1 genes are muatant

■ Neuronal migration occurs during — 12 TO 16 WEEKS of gestation.

■ structural abnormalities found in NMDs include

  1. schizencephaly,
  2. porencephaly,
  3. lissencephaly,
  4. agyria,
  5. macrogyria,
  6. polymicrogyria,
  7. pachygyria,
    8 ) microgyria,
  8. micropolygyria,
  9. neuronal heterotopias (including band heterotopia),
  10. agenesis of the corpus callosum,
  11. agenesis of the cranial nerves.

■ DIAGNOSIS :-
by MRI scan (shows a characteristic appearance of absent or abnormal areas of brain tissue. )