New hope from the 'seven year switch' in Type 1 diabetes

New hope from the ‘seven year switch’ in Type 1 diabetes

New research has shown that the rapid decline in insulin production that causes type 1 diabetes continues to fall over seven years and then stabilises.

  • A team found evidence that the amount of insulin produced declines by almost 50% each year for seven years.

  • At that point, the insulin levels stabilise.

  • The finding is a major step forward in understanding Type 1 diabetes and contradicts previous beliefs that the insulin produced by people with the condition drops relentlessly with time.

  • It offers the hope that by understanding what changes after seven years, new strategies could be developed to preserve insulin secreting beta-cells in patients.


    Beverley M. Shields, Timothy J. McDonald, Richard Oram, Anita Hill, Michelle Hudson, Pia Leete, Ewan R. Pearson, Sarah J. Richardson, Noel G. Morgan, Andrew T. Hattersley. C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase. Diabetes Care, 2018; dc180465 DOI: 10.2337/dc18-0465