New insight into how obesity, insulin resistance can impair cognition

Scientific Research - 2018 - (345):

New insight into how obesity, insulin resistance can impair cognition

_Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report.

_They knew that chronic activation of the receptor Adora2a on the endothelial cells that line this important barrier in our brain can let factors from the blood enter the brain and affect the function of our neurons.

_Now scientists have shown that when they block Adora2a in a model of diet-induced obesity, this important barrier function is maintained.

_People who have obesity and diabetes have higher rates of cognitive impairment as they age and most of the related structural changes are in the hippocampus, a center of learning and memory and Stranahan’s focus of study.

_Fat is a source of inflammation and there is evidence that reducing chronic inflammation in the brain helps prevent obesity-related memory loss.

Masaki Yamamoto, De-Huang Guo, Caterina M. Hernandez, Alexis M. Stranahan. Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. The Journal of Neuroscience, 2019; 2506-18 DOI: 10.1523/JNEUROSCI.2506-18.2019

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