Nude mice is not resistant to xenograft due to absence of

Nude mice is not resistant to xenograft
due to absence of
a) B cell
b) T cell
c) Both b and t cell
d) None
Correct Answer - B
Answer: B - T cell
Nude mice lacks “Thymus” & cannot generate mature T
lymphocytes.
Absence of T-lymphocytes makes it unable to mount adaptive
immune responsesrequiring CD4, helper T cells, CD8 and
cytotoxic T cells.
Adaptive immune responses that remain unresponsive to nude
mice include:
Antibody formation (CD4 + helper T cells)
Cell-mediated immune responses (CD4+ and/or CD8+ T cells)
Delayed-type hypersensitivity responses (CD4+ T cells)
Killing of virus-infected or malignant cells (CD8 + cytotoxic T cells)
Graft rejection (both CD4+ & CD8+ T cells)
Uses:
Laboratory study animal - Insights into immune system, leukemia,
solid tumors, AIDS & other immune deficiency diseases.
Absence of functioning T cells prevents them rejecting the allografts
& Xenografts