Poor mineralization of Bone
Poor mineralization of bone is a condition in which bones fail to mineralize properly, leading to weakened and brittle bones that are more prone to fractures. This condition is also known as osteomalacia in adults and rickets in children.
The mineralization of bone involves the deposition of calcium and phosphate ions onto the collagen matrix of the bone, resulting in the formation of hydroxyapatite crystals. This process is regulated by a variety of factors, including vitamin D, parathyroid hormone (PTH), calcium, and phosphate.
When there is a deficiency or dysfunction in any of these factors, it can lead to poor mineralization of bone. For example, vitamin D deficiency can impair the absorption of calcium and phosphate from the gut, which are necessary for bone mineralization. PTH deficiency or resistance can also impair the mobilization of calcium and phosphate from the bones, which are necessary for mineralization. Other conditions that can lead to poor mineralization of bone include chronic kidney disease, liver disease, and certain medications that can interfere with calcium and phosphate metabolism.
Symptoms of poor mineralization of bone can include bone pain, muscle weakness, and an increased risk of fractures. Treatment depends on the underlying cause but may include vitamin D and calcium supplementation, phosphate replacement, and management of any underlying medical conditions.