● presence of an intact cell within the cytoplasm of another cell.
● defined by as, “the active penetration of one cell by another which remains
● It differs from phagocytosis :- because the engulfed cell exists within another
cell and remains viable, and can exit without any physiological and morphological
changes in them.
● Etiopathogenesis of emperipolesis is uncertain.
● seen in
- hematolymphoid disorders e.g. myeloproliferative disorders, nonHodgkin’s
lymphoma, idiopathic myelofibrosis, myelodysplastic syndrome (MDS)
- Rosai-Dorfman disease.
- Autoimmune hepatitis.
- megakaryocytic emperipolesis is seen in ---- MDS.
- lymphocytes within Astrocytes (emperipolesis) in multiple sclerosis plaques and brain tumors.
- Lymphocytic- emperipolesis----CHRONIC LYMPHOCYTIC LEUKEMIA