Proteoglycan present in the glomerular
basement membrane is?
a) Keratan sulphate 1
b) Keratan sulphate 2
c) Heparan sulphate
d) Chondroitin sulphate
Correct Answer - C
Ans: c. Heparan sulphate
The glomerular membrane (or the filtration barrier) is the filtration
surface through which the fluid is filtered out from the blood.
The glomerular membrane (filtration barrier) comprises:
- The glomerular capillary endothelium.
- The basement membrane (basal lamina).
- The Bowman’s visceral epithelium (podocytes).
- Important constituents of glomerular membrane include,
- Laminin
- Type 4 collagen
- Nidogen
- Proteoglycans - (Heparan sulphate)
Ref: Arvind Arora review book of physiology (p. 371 - 372)