SDH deficient GIST is a ckit negative and hence non responsive to imatinib and hence they have indolent course. Hence it is a part of Carney startakis syndrome
SDH - deficient GISTs locate exclusively in the stomach, showing … Two of the wild-type GISTs were SDHB negative and showed IGF1R … Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors