Sepsis is a condition that arises when the

Sepsis is a condition that arises when the body’s response to infection causes injury to its own tissues and organs. Common signs and symptoms include fever, increased HR, increased breathing rate and confusion.

Severe sepsis is sepsis causing poor organ function or insufficient blood flow. Insufficient blood flow may be evident by low blood pressure, high blood lactate, or low urine output.

The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.

The Sepsis Six consists of three therapeutic and three diagnostic actions – all to be delivered within one hour of the initial diagnosis of sepsis:

  1. Administer empiric intravenous antibiotics

  2. Start intravenous fluid resuscitation

  3. Titrate oxygen to a saturation target of 94%

  4. Measure serial serum lactates

  5. Commence accurate urine output measurement.

  6. Take blood cultures and consider source control