Site is Thick ascending limb of loop of Henle

Site is Thick ascending limb of loop of Henle

Diuretics - Loop diuretics, MOA - inhibition of Na±K±2Cl- co transporter, this same channel is present on the stria vascularis of inner ear that’s why loop diuretics can cause ototoxicity especially Ethacrynic acid

Thick ascending limb of loop of henle

Loop diuretics inhibiting Na±K±2Cl- at the thick ascending limb of LOH

Defect in Na+/K+/2Cl- channel is seen in which syndrome?

its Bartter’s syndrome, it mimics chronic loop diuretic use

What is the inheritance pattern seen in Bartter’s?

Loop Diuretics(High Ceiling Diuretic) e.g Furosemide,Torsemide

What are the other Renal tubular syndromes? (other than Bartter’s)