Site of urea cycle – Biochemistry MCQ

Site of urea cycle is?

A. Liver
B. Kidney
D. Lungs

Correct answer : A. Liver
Site of urea cycle

Urea cycle (also known as ornithine cycle / Krebs Henseleit cycle) takes place in the liver
It is responsible for the conversion of toxic ammonia (produced by amino acid catabolism) to urea for excretion
5 enzymes are involved in the urea cycle are:
    Carbamoyl phosphate synthetase I
    Ornithine transcarbamylase
    Argininosuccinate synthase
    Argininosuccinate lyase (also known as argininosuccinase)
The first 2 enzymes are located in the mitochondria, whereas the other 3 are located in the cytoplasm
The rate limiting enzyme is Carbamoyl phosphate synthetase I