Site of urea cycle is?
A. Liver
B. Kidney
C. GIT
D. Lungs
Correct answer : A. Liver
Site of urea cycle
Urea cycle (also known as ornithine cycle / Krebs Henseleit cycle) takes place in the liver
It is responsible for the conversion of toxic ammonia (produced by amino acid catabolism) to urea for excretion
5 enzymes are involved in the urea cycle are:
Carbamoyl phosphate synthetase I
Ornithine transcarbamylase
Argininosuccinate synthase
Argininosuccinate lyase (also known as argininosuccinase)
Arginase
The first 2 enzymes are located in the mitochondria, whereas the other 3 are located in the cytoplasm
The rate limiting enzyme is Carbamoyl phosphate synthetase I