Speed of onset of local anesthetic increases with:
Decreased lipid solubility, high pka
value, more aqueous solubility,
and increased molecular weight
Increased lipid solubility, intermediate pKa value, less aqueous solubility, and decreased molecular weight
C Increased lipid solubility, high pka value, less aqueous solubility, and increased molecular weight
D Decreased lipid solubility, intermediate pka value, more solubility, and decreased molecular weight