Statins block vldl syn. In liver while BA resins incr. Vldl syn. How?

Statins block vldl syn. In liver while

BA resins incr. Vldl syn. How?

Statins lead to increased expression of the LDL receptor, resulting in an increase in the number of LDL receptors on the plasma membrane of hepatocytes leading to the accelerated clearance of apolipoprotein B and E containing lipoproteins (LDL and VLDL). Bile acid sequestrants bind to negatively charged bile acids and bile salts in the small intestine to interrupt the enterohepatic circulation of bile acids and increase the conversion of cholesterol into bile. Cholesterol synthesis also increases, which promotes VLDL secretion. Thank you.