The diagnosis based on the clinical history and the biopsy image is a case of Ulcerative colitis.
Clinical manifestations:
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Bloody diarrhea with mucus
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Fecal urgency
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Abdominal pain and cramps
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Tenesmus.
Gross findings:
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Inflamed, erythematous, edematous mucosa
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Friable mucosa with bleeding on contact with endoscope
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Fibrin-covered superficial broad-based ulcers
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Small mucosal ulcerations
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Pseudo-polyps and mucosal strings
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Later, Loss of mucosal folds & haustra, leading to lead-pipe appearance
HPE findings:
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Granulocyte (neutrophil) infiltration: limited to mucosa and submucosa
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Crypt abscesses and cryptitis; as seen in the image
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Basal layer plasmacytosis (a classical feature)
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Lymphocyte infiltration & Mucosal atrophy later.
Radiologically,
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earliest: fine mucosal granularity
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lead-pipe appearance in later stages
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toxic megacolon (complicated).
Associated with atypical p-ANCA antibody.
Risk of colon adenocarcinoma (more than crohns).
P.S. : rest of the options are for Crohn’s disease.