The enzyme inhibited by Hypoglycin G, which is responsible for these outbreaks is

Muzzafarpur is the “lychee bowl” of India. Recurrent outbreaks of poor, malnourished children of age ranging between 1 and 10, presenting with headache, vomiting, disorientation, delirium, convulsions, coma and death have been reported in the month of June since 1995.
In june 2019, a maximum of 440 children were admitted and 103 children died!
A toxin CYCLOPROPYLMETHYL GLYCIN or Hypoglycin G, found in lychee seeds, in lesser concentration in fruits, is found to be responsible for these outbreaks of “Acute encephalitis syndrome”
QUESTION 1:
The enzyme inhibited by Hypoglycin G, which is responsible for these outbreaks is

  • a. Glycogen phosphorylase
  • b. Glucose 6 phosphatase
  • c. Acetyl CoA carboxylase
  • d. Acyl coA dehydrogenase

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QUESTION 2
Why is the relevance of lower socioeconomic status in Acute encephalitis syndrome caused by hypoglycin G?

  • a. Absence of gluconeogenic precursors
  • b. Lack of energy
  • c. Absence of glycogen stores
  • d. Absence of glucagon

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