The following is an antiapoptotic gene -
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- Bax
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- Bad
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- Bcl-X
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- Bim
0 voters
exp:
Clinical importance of these genes.
- Inhibition of apoptosis results in uncontrolled cell proliferation and cancer.
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Human papilloma virus and cervical cancer.
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P53 protein is proapoptotic gene, i.e., it induces apoptosis.
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HPV produce a protein E6 that binds and inactivates p53 → ↓ Apoptosis → ↑ Cell survival and growth → Cervical carcinoma.
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EBV and B-cell lymphoma
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EBV produces a protein like BCL-2.
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BCL-2 inhibits apoptosis → B - cell lymphoma.
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Some other B-cell lymphomas also have high expression of BCl - 2.
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Melanoma
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In this tumor, there is decreased expression of Apaf-1.
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Apaf-1 is an antiapoptotic protein, Its decreased expression induce apoptosis and malignancy.
- Ionizing radiations and cytotoxic drugs cause DNA damage and induce apoptosis via tumor suppressor gene p53.