The proto oncogene associated with burkitt lymphoma is

The proto oncogene associated with burkitt lymphoma is

The proto-oncogene associated with Burkitt lymphoma is the MYC gene. In Burkitt lymphoma, there is a characteristic translocation involving the MYC gene, leading to its deregulation. The translocation involves the MYC gene on chromosome 8 and the immunoglobulin gene (usually IgH) on chromosome 14, resulting in the formation of the t(8;14) translocation.

This translocation places the MYC gene under the control of the immunoglobulin gene promoter, leading to increased expression of the MYC oncogene. The overexpression of MYC plays a crucial role in the development of Burkitt lymphoma by promoting uncontrolled cell proliferation and inhibiting apoptosis.

Burkitt lymphoma is a type of non-Hodgkin lymphoma that is often associated with Epstein-Barr virus (EBV) infection, particularly in endemic regions. The MYC translocation is a key genetic abnormality in the pathogenesis of Burkitt lymphoma and is considered a hallmark of this cancer.