Tissue factor activates?

Tissue factor activates?
a) Intrinsic pathway
b) Contact pathway
c) In vitro pathway
d) In vivo pathway
Correct Answer - D
Ans. D. In vivo pathway
[Ref Ganong 23thie p.5.31-53.5]
Blood coagulation pathways are divided into:-
Intrinsic pathway (contact pathway):
It is largely an ‘in vitro’ pathway and is activated when factor XII
(Hageman factor or contact factor) comes in contact with negatively
charged surface, e.g. glass, kaolin etc.
Extrinsic pathway:
It is largely an in vivo pathway is activated by tissue factor
(thromboplastin) at the site of tissue injury.