Total iron binding capacity(TIBC)

Total iron binding capacity(TIBC) is decreased in iron deficiency anemia and increased in anemia of chronic disease.

Iron deficiency anemia:
Depressed hemoglobin
Depressed hematocrit
Hypochromia
Microcytosis
Modest poikilocytosis
Serum iron low
Serum ferritin low
Total plasma iron binding capacity high
Reduction of transferrin saturation <15%
TIBC increases
Red cell protoporphyrin levels increase