Types of collagen, distribution and disorders

NEET PG Pathology
#1

TYPES OF COLLAGEN, DISTRIBUTION AND DISORDERS

  1. Fibrillar collagens

Type: I
Distribution: Bone, cornea, myofibrils
Disorder: Osteogenesis imperfecta, Ehler Danlos, arthrochalasias type I

Type: II
Distribution: Cartilage, intervertebral disc, vitreous
Disorder: Achondrogenesis type II, spondyloepiphysea dysplasia syndrome

Type: III
Distribution: Hollow organs, soft tissues, granulation tissue
Disorder: Vascular Ehlers Danlos

Type: V
Distribution: Soft tissues, blood vessels
Disorder: Classical Ehler Danlos

Type: IX
Distribution: Cartilage, vitreous
Disorder: Stickler syndrome

  1. Basement membrane collagens

Type: IV
Distribution: Basement membranes, eye lens
Disorder: Alport syndrome

  1. Other collagens

Type: VI
Distribution: Ubiquitous in microfibrils
Disorder: Bethlem myopathy

Type: VII
Distribution: Anchoring fibrils at dermal epidermal junctions
Disorder: Dystrophic epidermolysis bullosa

Type: IX
Distribution: Cartilage, intervertebral discs
Disorder: Multiple epiphyseal dysplasias

Type: XVII
Distribution: Transmembrane collagen in epidermal cells
Disorder: Benign atrophic generalized epidermolysis bullosa

Type: XV and XVIII
Distribution: Endostatin forming collagens, endothelial cells
Disorder: Knobloch syndrome