Typhoid is treated by all except
a) Erythromycin
b) Ceftriaxone
c) Amikacin
d) Ciprofloxacin
Correct Answer - A
Ans. is ‘a’ i.e., Erythromycin
The older agents used for the treatment of typhoid were :
Chloramphenicol
Ampicilin
Trimethoprim Sulfamethoxazole
Beta lactam
Parenteral → Ceftriaxone
Orall → Cefixime
These drugs are not used nowdays because of widespread
resistance. o Nowdays the drug of choice for Typhoid all over the
world is a “Fluroquinolone” (Ciprofloxacin, ofloxacin).
An important point to remember
High level of fluoroquinolone resistance (ciprofloxacin) have been
reported from India and other parts of South East Asia in S.
paratyphi and S.typhi infection.
Nalidixic acid resistant S.typhi (NARST) have decreased
ciprofloxacin sensitivity and are less effectively treated with
fluoroquinolones.
The fluroquinolones should not be used as first line treatment for
typhoid fevers in patients from India and other parts of South Asia
with high rates of fluroquinolone resistance unless antibiotic
susceptibility data demonstrates fluoroquinolone or nalidixic acid
sensitivity.