Urge criteria for restless leg syndrome

Restless Leg Syndrome:

U-Urge to move limbs
R-Rest or inactivity precipitates or worsens the symptoms
G-Getting up or moving improves the sensation
E-Evening or first-half of night time appearance or worsening

•Creepy-crawly or unpleasant
deep ache within the thighs or calves (very serious- arms).

•Nocturnal discomfort usually interferes with sleep, and patients may report daytime sleepiness as a consequence.

•Incidence: 5-10% (very common) ; Females and old people more.


1.)Primary: Genetic (AD)

2.) Secondary:

a.) Iron deficiency is the most common treatable cause, and iron replacement should be considered if the ferritin level is less than 50 ng/mL.

b.) Peripheral neuropathies and uremia.

c.) Pregnancy

•Can be worsened by pregnancy, caffeine,alcohol, antidepressants, lithium, neuroleptics, and antihistamines.

1.) 1st line: D2/3 agonists: Pramipexole,Ropinirole

2.) Other: Opioids,BZDs,Pregabalin and Gabapentin.