Vitamin C deficiency: ( Scurvy)
Pathology : Poor osteoid formation.
Clinical features:-
- Irritability is predominant.
- Scorbutic Rosary - ( angular and sharp costochondral junction )
Radiological findings:-
- White line of Frankel
- Pelkan Spur
- Wimberger ring sign
- Sub periosteal hemorrhage.
Note: Irritability in scurvy is due to hampered neurotransmitter production ( conversion of dopamine to norepinephrine and tryptophan to serotonin requires vitamin c ).