What happens In acidosis...hyperkalemia or hypokalemia?....and how does raas activation can cause hypokalemia?

What happens In acidosis…hyperkalemia or hypokalemia?..and how does raas activation can cause hypokalemia?

In acidosis, hyperkalemia can occur. Acidosis is a condition in which there is an excess of acid in the blood, resulting in a decrease in blood pH. When the blood pH decreases, hydrogen ions (H+) move from the extracellular fluid into the cells, in exchange for potassium ions (K+), leading to an increase in serum potassium levels.

On the other hand, activation of the renin-angiotensin-aldosterone system (RAAS) can cause hypokalemia. The RAAS is a hormone system that regulates blood pressure and fluid balance in the body. When the blood pressure decreases or the sodium levels are low, the kidneys release the enzyme renin, which converts angiotensinogen into angiotensin I. Angiotensin I is then converted into angiotensin II by the angiotensin-converting enzyme (ACE), which causes vasoconstriction and increases blood pressure.

Angiotensin II also stimulates the release of aldosterone from the adrenal glands. Aldosterone acts on the kidneys to increase the reabsorption of sodium and the excretion of potassium in the urine, leading to hypokalemia.

In summary, in acidosis, hyperkalemia can occur, whereas activation of the RAAS can cause hypokalemia. Acidosis can lead to an intracellular shift of potassium ions out of cells and into the extracellular space, while RAAS activation can increase urinary potassium excretion and decrease serum potassium levels.