What is mechanism of action of colchicine in acute gout?

What is mechanism of action of colchicine
in acute gout?
a) Inhibition of purine metabolism
b) Inhibition of uric acid conversion
c) Migration of leukocytes
d) Leukocytes, lymphocytes inhibition & microtubular inhibitor
Correct Answer - D
Answer: D - Leukocytes, Lymphocytes migration inhibition &
microtubular inhibitor.
Colchicine acts by inhibiting the granulocyte migration into the
inflamed joint.
An alkaloid from Colchium autumnale
Specifically suppresses gouty inflammation.
Doesn’t inhibit the synthesis or promote the excretion of uric acid.
Mechanism of action:
Colchicine acts by, inhibits the release of glycoprotein
Binds to fibrillar protein tubules inhibiting granulocyte
migration into the inflamed joint.
An acute attack of gout starts by precipitation of urate crystals in
synovial fluid.
Inflammatory response starts with granulocyte migration into joint
Phagocytosing urate crystals releasing glycoprotein
Glycoprotein increases lactic acid production and releasing
lysosomal enzymes causing more joint destruction.