What is mechanism of action of
Curanium drugs as muscle relaxant?
a) Persistently depolarizing at Neuromuscular junction
b) Act competitively on Ach receptors blocking post-synaptically
c) Repetitive stimulation of Ach receptors on muscle end plate
d) Inhibiting the calcium channel on presynaptic membrane
Correct Answer - B
Answer: B - Act competitively on Ach receptors blocking post-
synaptically
Candocuronium iodide is an aminosteroid neuromuscular-blocking
drug or skeletal muscle relaxant in the category of non-depolarizing
neuromuscular-blocking drugs.
Acts on Ach receptors competitively post-synaptically blocking them.
Potential adjunctive use in anaesthesia to facilitate endotracheal
intubation & provide skeletal muscle relaxation.
Candocuronium demonstrated a short duration and a rapid onset of
action, with little or no ganglion blocking activity, and it was only
slightly less potent than pancuronium