A 40-year-old female is referred to medical assessment unit by her physician for querying thrombotic thrombocytopenic purpura (TTP) after she presented with a temperature of 38.9ºC. Her subsequent urea and electrolytes showed deteriorating renal function with a creatinine 3 times greater than her baseline.
What is the underlying pathophysiology of TTP?
Autoimmune destruction of red blood cells
Failure to cleave von Willebrand factor normally
Anti-bodies against von Willebrand factor
Autoimmune destruction of platelets
A deficiency of von Willebrand factor