Which is contraindicated in asthma pt Carboprost

Which is contraindicated in asthma pt

Carboprost

carboprost (also known as 15-methyl prostaglandin F2α) is contraindicated in patients with asthma.

Carboprost and Asthma:

  • Reason for Contraindication:
    • Carboprost is a potent uterotonic agent used primarily to manage postpartum hemorrhage by inducing uterine contractions. However, it can cause bronchoconstriction, which can exacerbate asthma or other respiratory conditions. This bronchoconstriction is due to the prostaglandin F2α’s action on bronchial smooth muscle.

Alternative Options:

  • For Asthmatic Patients:
    • Methylergometrine (Methergine) and oxytocin (Pitocin) are often used as alternatives to carboprost for managing postpartum hemorrhage in asthmatic patients. These alternatives are generally considered safer as they are less likely to induce bronchoconstriction.

General Considerations:

  • Medical History: Always consider a patient’s complete medical history and comorbid conditions when selecting medications, particularly in patients with conditions like asthma that may be adversely affected by certain drugs.
  • Monitoring: If carboprost must be used in a patient with asthma due to its critical role in managing postpartum hemorrhage, close monitoring and premedication with bronchodilators might be necessary.

Summary:

Carboprost is contraindicated in asthmatic patients because of its potential to induce bronchoconstriction. Safer alternatives, such as methylergometrine and oxytocin, are preferred in these cases.