Which of the following accurately represents one aspect of the pathogenesis of T1DM?

A 28-year-old man with type 1 diabetes comes to the clinic with his wife. They want to know about the aetiology of type 1 diabetes (T1DM) and the chances of any offspring inheriting the disease.
Which of the following accurately represents one aspect of the pathogenesis of T1DM?

50% of patients developing the disease have a positive family history
All patients are ZnT8 autoantibody positive
Enteroviruses may play a role in protection from and susceptibility to T1DM  This is the correct answer
The disease is primarily mediated by pathogenic B cells
There is 100% twin concordance

Accumulating evidence suggests that enteroviruses may play a role in both protection from and
susceptibility to type 1 diabetes. A large cohort study has demonstrated that decline in C peptide in at
risk individuals is associated with positive markers for enterovirus infection, and it is quite plausible
that autoimmune attack on beta cells stems from an abnormal response to local viral infection.
Type 1 diabetes is a primarily T cell mediated disorder. Whilst autoantibodies to beta cell antigens are
measurable in patients with the disease, they are not thought to play direct role in its pathogenesis.
ZnT8 is found within the beta cell; whilst ZnT8 autoantibodies are often positive in patients with type 1
diabetes, it is not invariable.
Conventionally, anti-GAD and anti-IA2 antibodies are measured to support the diagnosis.
Only 10% of patients have a positive family history, and there is 30-50% twin concordance.