Which of the following adverse effect of
ACE inhibitors is not due to bradykinin ?
a) Cough
b) Angiodema
c) Hypotension
d) None of the above
Correct Answer - C
Ans. C. Hypotension
Bradykinin and sustance P are substrate for ACE.
ACE inhibitors increase level of these kinins by inhibiting ACE, which
is responsible for cough and angiodema.
Cough and angioedema are due to elevated bradykinin, caused by
inhibition of bradykinin/srbstance P metabolism in lungs.