Which of the following circulating
antibodies has the best sensitivity and
sepcificity for the diagnosis of celiac
disease ?
a) Anti Saccharomyces antibody
b) Anti-tissue transglutaminase antibody
c) Anti-gliadin antibody
d) Anti-gliadin antibody antibody
Correct Answer - A
Ans. is ‘a’ i.e. Anti saccharomyces antibody
Serologic evaluation in celiac disease
Immunoglobulin A (IgA) anti-tissue transglutaminase (TTG) antibody
is the single preferred test for detection of celiac disease in
individuals over the age of two years.
Serum antibody assays
A variety of serologic studies have been described to aid in the
diagnosis of celiac disease, including:
IgA endomysial antibody (IgA EMA)
IgA tissue transglutaminase antibody (IgA tTG)
IgG tissue transglutaminase antibody (IgG tTG)
IgA deamidated gliadin peptide (IgA DGP)
IgG deamidated gliadin peptide (IgG DGP)
Serum IgA endomysial and tissue transglutaminase antibody testing
have the highest diagnostic accuracy.
The IgA and IgG antigliadin antibody tests have lower diagnostic
accuracy with frequent false positive results as compared with IgA
tTG and IgA DGP assays and are therefore no longer recommended