Which of the following is known as
suicidal enzyme?
a) Lipoxygenase
b) Cyclooxygenase
c) Thromboxane synthatase
d) 5’ nucleotidase
Correct Answer - B
Suicidal enzyme is one, which undergoes self-destruction in order to
terminate its own acitivity, e.g. Cyclooxygenase.
Suicidal Inhibition is conversion of a substrate by the enzyme into a
metabolite, which is a potent inhibitor of the enzyme; example:
Xanthine oxidase converts allopurinol to alloxanthine (oxypurinol),
which is a more potent inhibitor of allopurinol.
Cycloorygenase is known as suicide enzyme because it
catalyzes its own destruction.