Which of the following is most likely the primary cause of this patient’s symptoms?

A 53-year-old woman presents with irregular menstrual periods. She claims that she sometimes goes two-three months without a period. On further questioning, she also complains of vaginal dryness and occasional hot flashes. Blood tests reveal an estrogen level of 22 pg/mL (normal: 60-400 pg/mL), follicle-stimulating hormone (FSH) level of 100 mIU/L (normal: 1-26 mIU/L), and luteinizing hormone level of 50 mIU/mL (normal: 1-12 mIU/L), without surge. Which of the following is most likely the primary cause of this patient’s symptoms?

(A) Decreased estrogen levels
(B) Decreased feedback on the anterior pituitary
© Increased FSH levels
(D) Increased progesterone levels
(E) Increased testosterone levels