Which of the following is the most
common anamoly in patients with
fanconi’s anemia?
a) Hyperpigmentation of the trunk, neck and intertriginous areas
b) Absent radii and thumb
c) Weak radial pulse
d) Presence of horse shoe kidneys
Correct Answer - A
Answer- A. Hyperpigmentation of the trunk, neck and
intertriginous areas
Fanconi anemia (FA) is primarily inherited in an autosomal recessive
manner (one uncommon form is X-linked recessive).
The most common anomaly in FA is hyperpigmentation of the trunk,
neck, and intertriginous areas, as well as café-au-lait spots and
vitiligo, alone or in combination.
Anomalies of the feet, congenital hip dislocation, and leg
abnormalities are seen.