Which of the following tetracyclines remains unchanged when the drug is administered to an anuric patient?

The elimination half-life of which of the following tetracyclines remains unchanged when the drug is administered to an anuric patient?

1.Methacycline
2.Oxytetracycline
3.Doxcycline
4.Tetracycline
5.None of the above

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All tetracyclines can produce negative nitrogen balance and increased blood urea nitrogen (BUN) levels. This is of clinical importance in patients with impaired renal function. With the exception of doxycycline, tetracyclines should not be used in patients that are anuric. Doxycycline is excreted by the GI tract under these conditions, and it will not accumulate in the serum of patients with renal insufficiency.